A dysregulated inflammatory response is observed in various diseases, such as rheumatoid arthritis, diabetes, cancer, and Alzheimer’s disease as well as pulmonary, cardiovascular, and autoimmune diseases. Inflammation involves a complex network of many mediators, a variety of cells, and execution of multiple pathways.
Traditionally, therapeutic regimens for inflammation include the use of steroidal and non-steroidal anti-inflammatory agents. However, these drugs may provoke severe adverse effects, including osteoporosis, gastrointestinal abnormalities, cardiovascular events, and renal disorders. Moreover, drug resistance may occur in a subpopulation of patients. There is an urgent need to explore new anti-inflammatory agents with selective effects and lower toxicity. Although various in vivo and in vitro models are available for anti-inflammatory drug development, wise selection of appropriate animal models is a key step in the early phase of drug development.
Creative Bioarray offers a large number of validated acute, chronic and immune-mediated pharmacological models and a series of preclinical services, enabling customers to screen potential anti-inflammatory agents as well as identify novel therapeutic targets. Screening of compounds can be performed in existing well-characterized animal models or in newly developed animal models customized for specific test items.
